By Jocelyn Kaiser Mar. 1, 2021 , 11:00 AM Researchers have shown in mice that designer antibodies can curb the growth of tumors by targeting two of cancer’s most infamous offenders—the proteins RAS and p53, which are mutated in many tumors but have largely defied drug development efforts. If their promise holds up in clinical trials, such drugs could make it possible to unleash the body’s immune system on hard-to-treat cancers including pancreatic and ovarian. “It’s exciting,” says immunologist Jon Weidanz of the University of Texas, Arlington, who co-founded a company that works on similar immunotherapies, called bispecific antibodies. The new drugs can lock onto a few snippets of p53 or RAS jutting out from a tumor cell’s surface—and then trigger immune cells to attack them. “The therapies have the potential to work when there’s a really low number of the target on cells. That is a big deal,” says Weidanz, who wrote a commentary accompanying the papers. P53 is a tumor … [Read more...] about New immunotherapy drugs target two evasive cancer-driving proteins
La Samsung Galaxy Watch 3 est la remplaçante très attendue de l’une de nos montres connectées préférées, la Samsung Galaxy Watch originale, qui figure toujours en première position de notre top des meilleures smartwatches bien qu'elle ait quelques années déjà. Et non, vous n'avez rien manqué : il n'y a pas de Galaxy Watch 2. Samsung a préféré faire un bond en avant et doubler la sportive Samsung Galaxy Watch Active 2 pour nommer sa prochaine montre connectée, la Galaxy Watch 3. Mais nous n’avons pas d’explication précise quant à cette décision. Cette nouvelle montre intelligente possède un design plus fin et de meilleures caractéristiques, ce qui est normal, étant donné que la première montre Galaxy est sortie en août 2018, il y a deux ans. Elle dispose de plus de fonctions de santé et d'entraînement, d'un ECG, d'un contrôle de l'oxygène sanguin SPO2 et d'un suivi de la tension artérielle. La vraie question est de savoir si les améliorations apportées sont suffisantes pour … [Read more...] about Samsung Galaxy Watch 3 vs Samsung Galaxy Watch: quelle est la meilleure smartwatch ?
Amazon Prime Video has gathered an impressive lineup of original shows to keep you entertained. It's also picked up excellent programs from other countries to stream in the US. Thankfully, those exclusives, like A Very English Scandal and Catastrophe, can be appreciated by a wider audience. Let's round up the best TV shows Amazon has to offer. CNET Culture Entertain your brain with the coolest news from streaming to superheroes, memes to video games. Read more : The 20 best movies to watch on Amazon Prime Video | Everything you need to know to sign up to Amazon Prime Video Informer Amazon Studios This gripping British series is about, yes, an informer, and the murky territory involved in coercing someone to take on the dangerous gig. Paddy Considine (who now has a gig on the Game of Thrones prequel) stars as DS Gabe Waters, a counterterrorism officer tasked with infiltrating a far-right movement in West Yorkshire. Partnered with an excellent … [Read more...] about The 22 best TV shows to binge on Amazon Prime Video
What do the biggest social media influencers and creators have in common? They reigned supreme at VidCon 2016 . Oh, and they were also in attendance at the second-annual, invite-only, Back to the Future -themed Rise9 bash. Rise9 and Diply , with Mashable by their side, took guests back in time. The #ThrowBacktotheFuture party boasted a real-life DeLorean, a 50’s barbershop quartet, and Ring Pops galore. Hosted at Highway 39 Events Center, a vintage car museum in Anaheim, CA, the whole trip to the past was brought to life. More from last night. #throwbacktothefuture #bttf A photo posted by Dustin McLean (@dustfilms) on Jun 25, 2016 at 6:17pm PDT The ultimate throwback? A live performance of “I Want Candy” by the early 2000s pop sensation himself, Aaron Carter. Carter also treated the audience to more of his classics as well as introduced songs from his upcoming album. #ThrowBackToTheFuture #Rise9 event #VidCon A photo posted by Aaron Cårter … [Read more...] about We threw it back to the future with Rise9 at VidCon 2016